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KMID : 1134820150440040483
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Journal of the Korean Society of Food Science and Nutrition
2015 Volume.44 No. 4 p.483 ~ p.490
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Anti-Hypertensive Effects of Black Raspberry (Rubus occidentalis) in Spontaneously Hypertensive Rats (SHR)
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Lee Jung-Hyun
Choi Hye-Ran
Lee Su-Jung
Lee Min-Jung
Jang Ji-Eun
Kwon Ji-Wung
Park Pill-Jae
Lee Tae-Bum
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Abstract
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The purpose of this study was to investigate the effects of 50% ethanol extracts of ripe black raspberry (Rubus occidentalis, RBR) on hypertension in spontaneously hypertensive rats (SHR). The final systolic blood pressure of the group treated with RBR for 12 weeks was significantly lower than that of the SHR group. The mRNA expression level of endothelial nitric oxide synthase (eNOS) was significantly decreased in SHR. However, treatment with RBR and captopril increased the level of eNOS mRNA in SHR. Moreover, plasma levels of homocysteine and plasminogen activator inhibitor-1 were significantly reduced by RBR. Plasma total cholesterol, high-density lipoprotein, and low-density lipoprotein cholesterol levels were lower in SHR than Wistar Kyoto rats (WKY). However, there was no significant difference in plasma triglyceride level between WKY and SHR. The number of eosinophilic cardiac muscle cells was reduced in heart muscles after treatment with captopril and RBR. Therefore, this study suggests that RBR extracts may be useful for improvement of hypertension.
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KEYWORD
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black raspberry, hypertension, endothelial nitric oxide synthase, homocysteine, plasminogen activator inhibitor-1
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